Action of chlorpromazine. 3. Mitochondrial adenosine triphosphatase and the adenosine triphosphate–adenosine diphosphate exchange*
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چکیده
منابع مشابه
The adenosine triphosphate-adenosine diphosphate exchange reaction of oxidative phosphorylation.
Previous reports from this laboratory have demonstrated that the ATP-Pi32 1 exchange reaction (1) and the dinitrophenolstimulated ATPase activity (2) of mitochondrial subfragments (3-9) are reflections of intermediate enzymatic steps in the complex sequence of reactions (1, 3) in which phosphorylation of ADP is coupled to electron transport in the respiratory chain. This communication concerns ...
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Previous studies reported from this and other Laboratories have shown that isolated mitochondria are able to maintain concentration gradients of Na+ and K+ ions. When incubated in media containing an oxidizable substrate and ATP, mitochondria from liver (Macfarlane & Spencer, 1953; Spector, 1953; Price, Fonnesu & Davies, 1956), kidney (Bartley & Davies, 1954; Ulrich, 1961), heart and skeletal m...
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1. The mitochondrial ATPase of Acanthamoeba castellanii accumulated discontinuously in synchronous cultures prepared by a minimally perturbing size-selection technique. 2. Enzyme activity per ml of culture doubled overall during one cell cycle time of 8h, but oscillated to give seven maxima during this period. Similar oscillations were observed in the specific activities of ATPase and of the na...
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Membrane hyperpolarization appears to be an important mechanism of vasodilation induced by many pharmacological and endogenous vasodilators. The objective of the present study was to determine the mechanisms of vasodilation induced by ADP, an endogenous vasodilator, in various resistance arteries isolated from the rabbit. ADP hyperpolarized (12-15 mV) and relaxed mesenteric and skeletal muscle ...
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The kinetics of protein-fluorescence change when rabbit skeletal myosin subfragment 1 is mixed with ATP or adenosine 5'-(3-thiotriphosphate) in the presence of Mg(2+) are incompatible with a simple bimolecular association process. A substrate-induced conformation change with DeltaG(0)<-24kJ.mol(-1) (i.e. DeltaG(0) could be more negative) at pH8 and 21 degrees C is proposed as the additional ste...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1960
ISSN: 0306-3283
DOI: 10.1042/bj0760200